Inherited and acquired determinants of serum tryptase levels in humans.
Ann Allergy Asthma Immunol
; 127(4): 420-426, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34175497
ABSTRACT
OBJECTIVE:
To aid the clinician in correctly interpreting serum tryptase levels. DATA SOURCES Primary peer-reviewed literature. STUDY SELECTIONS Clinical and basic science peer-reviewed studies characterizing the genetic and physiological bases for tryptase generation, secretion, and elevation, including those describing serum tryptase levels in population-based cohort studies.RESULTS:
Clinically measured basal serum tryptase (BST) consists of ostensibly inactive alpha- and beta-tryptase precursors. The autosomal dominant genetic trait hereditary alpha-tryptasemia is the most often cause for elevated BST levels, with other acquired causes, such as renal failure and clonal myeloid diseases being far less common. Acute increases in serum tryptase levels resulting from release of mature tryptase from secretory granules is specific to mast cell degranulation but is not detected in all cases of systemic anaphylaxis.CONCLUSION:
Understanding the differences and distinguishing between acute increases in serum tryptase and chronic elevations in BST owing to inherited or acquired conditions is critical in the correct interpretation of this useful clinical biomarker.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mastocytosis
/
Enzyme Precursors
/
Tryptases
/
Mast Cells
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Ann Allergy Asthma Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2021
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA