Your browser doesn't support javascript.
loading
Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020.
Antinori, Spinello; Giacomelli, Andrea; Corbellino, Mario; Torre, Alessandro; Schiuma, Marco; Casalini, Giacomo; Parravicini, Carlo; Milazzo, Laura; Gervasoni, Cristina; Ridolfo, Anna Lisa.
Affiliation
  • Antinori S; Luigi Sacco Department of Biomedical and Clinical Sciences, Università di Milano, 20157 Milan, Italy.
  • Giacomelli A; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
  • Corbellino M; Luigi Sacco Department of Biomedical and Clinical Sciences, Università di Milano, 20157 Milan, Italy.
  • Torre A; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
  • Schiuma M; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
  • Casalini G; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
  • Parravicini C; Luigi Sacco Department of Biomedical and Clinical Sciences, Università di Milano, 20157 Milan, Italy.
  • Milazzo L; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
  • Gervasoni C; Luigi Sacco Department of Biomedical and Clinical Sciences, Università di Milano, 20157 Milan, Italy.
  • Ridolfo AL; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
J Fungi (Basel) ; 7(6)2021 Jun 14.
Article in En | MEDLINE | ID: mdl-34198597
ABSTRACT
Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been some autochthonous cases, especially in Italy; however, most European physicians are unfamiliar with its clinical and pathological picture, particularly among immunocompromised patients without HIV infection. This systematic review of all the cases of histoplasmosis reported in Europe and Israel between 2005 and 2020 identified 728 cases diagnosed in 17 European countries and Israel described in 133 articles. The vast majority were imported (mainly from Central and South America), but there were also seven autochthonous cases (six in Europe and one in Israel). The patients were prevalently males (60.4%), and their ages ranged from 2 to 86 years. The time between leaving an endemic region and the diagnosis of histoplasmosis varied from a few weeks to more than 40 years. Progressive disseminated histoplasmosis was the most frequent clinical picture among people living with HIV infection (89.5%) or a different immunocompromising condition (57.1%), but it was also recorded in 6.2% of immunocompetent patients. Twenty-eight cases were caused by Histoplasma duboisii. Immunocompromised patients without HIV infection had the worst outcomes, with a mortality rate of 32%.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Systematic_reviews Language: En Journal: J Fungi (Basel) Year: 2021 Document type: Article Affiliation country: Italia

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Systematic_reviews Language: En Journal: J Fungi (Basel) Year: 2021 Document type: Article Affiliation country: Italia
...