Atomically Dispersed Co to an End-Adsorbing Molecule for Excellent Biomimetically and Prime Sensitively Detecting O2â¢- Released from Living Cells.
Anal Chem
; 93(31): 10789-10797, 2021 08 10.
Article
in En
| MEDLINE
| ID: mdl-34212722
ABSTRACT
Single-atom catalysis efficiently exposes the catalytic sites to reactant molecules while rendering opportunity to investigate the catalysis mechanisms at atomic levels for scientific insights. Here, for the first time, atomically dispersed Co atoms are synthesized as biomimetic "enzymes" to monitor superoxide anions (O2â¢-), delivering ultraordinary high sensitivity (710.03 µA·µM-1·cm-2), low detection limit (1.5 nM), and rapid response time (1.2 s), ranking the best among all the reported either bioenzymatic or biomimetic O2â¢- biosensors. The sensor is further successfully employed to real-time monitor O2â¢- released from living cells. Moreover, theoretical calculation and analysis associated with experimental results discover that a mode of end adsorption of the negatively charged O2â¢- on the Co3+ atom rather than a bridge or/and side adsorption of the two atoms of O2â¢- on two Co3+ atoms, respectively, plays an important role in the single-atomic catalysis toward O2â¢- oxidation, which not only facilitates faster electron transfer but also offers better selectivity. This work holds great promise for an inexpensive and sensitive atomic biomimetic O2â¢- sensor for bioresearch and clinic diagnosis, while revealing that the adsorption mode plays a critical role in single-atom catalysis for a fundamental insight.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biosensing Techniques
Type of study:
Diagnostic_studies
Language:
En
Journal:
Anal Chem
Year:
2021
Document type:
Article
Affiliation country:
China