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Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis.
Yuan, Renyikun; Zhao, Wentong; Wang, Qin-Qin; He, Jia; Han, Shan; Gao, Hongwei; Feng, Yulin; Yang, Shilin.
Affiliation
  • Yuan R; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China.
  • Zhao W; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China.
  • Wang QQ; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530020, China.
  • He J; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530020, China.
  • Han S; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530020, China.
  • Gao H; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530020, China. Electronic address: gaohongwei06@126.com.
  • Feng Y; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: fengyulin2003
  • Yang S; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530020, China.
Pharmacol Res ; 170: 105748, 2021 08.
Article in En | MEDLINE | ID: mdl-34217831
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Carcinoma, Non-Small-Cell Lung / Phosphate-Binding Proteins / Toll-Like Receptor 4 / Pore Forming Cytotoxic Proteins / Inflammasomes / Pyroptosis / NLR Family, Pyrin Domain-Containing 3 Protein / Lung Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Carcinoma, Non-Small-Cell Lung / Phosphate-Binding Proteins / Toll-Like Receptor 4 / Pore Forming Cytotoxic Proteins / Inflammasomes / Pyroptosis / NLR Family, Pyrin Domain-Containing 3 Protein / Lung Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: Países Bajos