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Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis.
Lechner, Kristina; Mott, Stefanie; Al-Saifi, Ragheed; Knipfer, Lisa; Wirtz, Stefan; Atreya, Raja; Vieth, Michael; Rath, Timo; Fraass, Tina; Winter, Zoltan; August, Avery; Luban, Jeremy; Zimmermann, Valérie S; Weigmann, Benno; Neurath, Markus F.
Affiliation
  • Lechner K; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Mott S; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Al-Saifi R; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Knipfer L; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Wirtz S; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Atreya R; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Vieth M; Institute of Pathology, Klinikum Bayreuth, University of Erlangen-Nuremberg, Erlangen Germany.
  • Rath T; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  • Fraass T; Optical Imaging Center, Erlangen, Germany.
  • Winter Z; Optical Imaging Center, Erlangen, Germany.
  • August A; Department of Microbiology and Immunology, Cornell University, Ithaca, New York.
  • Luban J; Program in Molecular Medicine and Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.
  • Zimmermann VS; Institut de Génétique Moléculaire de Montpellier, University of Montpellier, Le Centre National de la Recherche Scientifique, Montpellier, France.
  • Weigmann B; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany; Medical Immunology Campus Erlangen, Medical Clinic 1, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Neurath MF; Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Erlangen, Germany. Electronic address: markus.neurath@uk-erlangen.de.
Gastroenterology ; 161(4): 1270-1287.e19, 2021 10.
Article in En | MEDLINE | ID: mdl-34224738
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Colitis, Ulcerative / Colon / Protein Kinase Inhibitors / Intraepithelial Lymphocytes / Intestinal Mucosa / Anti-Inflammatory Agents Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Colitis, Ulcerative / Colon / Protein Kinase Inhibitors / Intraepithelial Lymphocytes / Intestinal Mucosa / Anti-Inflammatory Agents Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Estados Unidos