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Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice.
Garai, János; Krekó, Marcell; Orfi, László; Jakus, Péter Balázs; Rumbus, Zoltán; Kéringer, Patrik; Garami, András; Vámos, Eszter; Kovács, Dominika; Bagóné Vántus, Viola; Radnai, Balázs; Lóránd, Tamás.
Affiliation
  • Garai J; Department of Pathophysiology, Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
  • Krekó M; Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary.
  • Orfi L; Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary.
  • Jakus PB; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
  • Rumbus Z; Department of Thermophysiology, Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
  • Kéringer P; Department of Thermophysiology, Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
  • Garami A; Department of Thermophysiology, Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
  • Vámos E; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
  • Kovács D; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
  • Bagóné Vántus V; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
  • Radnai B; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
  • Lóránd T; Department of Biochemistry and Medical Chemistry, University of Pécs, Medical School, Pécs, Hungary.
J Enzyme Inhib Med Chem ; 36(1): 1357-1369, 2021 Dec.
Article in En | MEDLINE | ID: mdl-34225560
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrophage Migration-Inhibitory Factors / Tetralones / Hypothermia, Induced Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Hungria Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrophage Migration-Inhibitory Factors / Tetralones / Hypothermia, Induced Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Hungria Country of publication: Reino Unido