Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies.
Development
; 148(13)2021 07 01.
Article
in En
| MEDLINE
| ID: mdl-34228796
ABSTRACT
The trachea delivers inhaled air into the lungs for gas exchange. Anomalies in tracheal development can result in life-threatening malformations, such as tracheoesophageal fistula and tracheomalacia. Given the limitations of current therapeutic approaches, development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review, recent advances in mammalian tracheal development and the generation of tracheal tissues from pluripotent stem cells are summarized.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trachea
/
Tracheoesophageal Fistula
/
Lung
/
Morphogenesis
Limits:
Animals
/
Humans
Language:
En
Journal:
Development
Journal subject:
BIOLOGIA
/
EMBRIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Japón