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An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression.
Nguyen, Thao Thi Thanh; Shingyoji, Masato; Hanazono, Michiko; Zhong, Boya; Morinaga, Takao; Tada, Yuji; Shimada, Hideaki; Hiroshima, Kenzo; Tagawa, Masatoshi.
Affiliation
  • Nguyen TTT; Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan.
  • Shingyoji M; Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Hanazono M; Division of Medical Biotechnology, Biotechnology Center of Ho Chi Minh City, 2374 National Highway 1, District 12, Ho Chi Minh, Vietnam.
  • Zhong B; Division of Respirology, Chiba Cancer Center, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan.
  • Morinaga T; Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan.
  • Tada Y; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Shimada H; Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan.
  • Hiroshima K; Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Tagawa M; Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan.
Cell Death Dis ; 12(7): 663, 2021 07 02.
Article in En | MEDLINE | ID: mdl-34230456
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Adenoviridae / Tumor Suppressor Protein p53 / Adenovirus E1 Proteins / Neurofibromin 1 / Imidazolines / Oncolytic Viruses / Proto-Oncogene Proteins c-mdm2 / Oncolytic Virotherapy / Imidazoles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Death Dis Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Adenoviridae / Tumor Suppressor Protein p53 / Adenovirus E1 Proteins / Neurofibromin 1 / Imidazolines / Oncolytic Viruses / Proto-Oncogene Proteins c-mdm2 / Oncolytic Virotherapy / Imidazoles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Death Dis Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Reino Unido