A yeast-based screening system identified bakkenolide B contained in Petasites japonicus as an inhibitor of interleukin-2 production in a human T cell line.

Uesugi, Shota; Hakozaki, Mayuka; Kanno, Yuko; Takahashi, Honoka; Kudo, Yui; Kimura, Ken-Ichi; Yamada, Hidetoshi; Yano, Akira

Uesugi, Shota; Hakozaki, Mayuka; Kanno, Yuko; Takahashi, Honoka; Kudo, Yui; Kimura, Ken-Ichi; Yamada, Hidetoshi; Yano, Akira.

Affiliation

Uesugi S; Iwate Biotechnology Research Center, Kitakami, Iwate, Japan.
Hakozaki M; Iwate Biotechnology Research Center, Kitakami, Iwate, Japan.
Kanno Y; Iwate Biotechnology Research Center, Kitakami, Iwate, Japan.
Takahashi H; Graduate School of Arts and Sciences, Graduate Course in Biological Chemistry and Food Science, Iwate University, Morioka, Iwate, Japan.
Kudo Y; Graduate School of Arts and Sciences, Graduate Course in Biological Chemistry and Food Science, Iwate University, Morioka, Iwate, Japan.
Kimura KI; Graduate School of Arts and Sciences, Graduate Course in Biological Chemistry and Food Science, Iwate University, Morioka, Iwate, Japan.
Yamada H; Iwate Biotechnology Research Center, Kitakami, Iwate, Japan.
Yano A; Department of Life and Health Sciences, Teikyo University of Science, Adachi-ku, Tokyo, Japan.

Biosci Biotechnol Biochem ; 85(10): 2153-2160, 2021 Sep 22.

Article in En | MEDLINE | ID: mdl-34251393

Subject(s)
Key words

Ca2+ signaling; Petasites japonicus; bakkenolide B; interleukin-2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Sesquiterpenes Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Reino Unido

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