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High oxygen concentrations inhibit Acanthamoeba spp.
Sifaoui, Ines; -Yanes, Eulalia Capote; Reyes-Batlle, María; Rodríguez-Expósito, Rubén L; Bazzocchi, Isabel L; Jiménez, Ignacio A; Piñero, José E; Lorenzo-Morales, Jacob; Weaver, Lindell K.
Affiliation
  • Sifaoui I; Instituto Universitario De Enfermedades Tropicales Y Salud Pública De Canarias, Universidad De La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Islas Canarias, Spain. isifaoui@ull.edu.es.
  • -Yanes EC; Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva Y Salud Pública, Toxicología, Medicina Legal Y Forense Y Parasitología, Universidad De La Laguna, La Laguna, Tenerife, Spain. isifaoui@ull.edu.es.
  • Reyes-Batlle M; Red de Investigación Cooperativa en Enfermedades Tropicales (RICET), Madrid, Spain. isifaoui@ull.edu.es.
  • Rodríguez-Expósito RL; Instituto Universitario De Enfermedades Tropicales Y Salud Pública De Canarias, Universidad De La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Islas Canarias, Spain.
  • Bazzocchi IL; Servicio de Oftalmología, Hospital Universitario Nuestra Señora de La Candelaria, Canarias, Tenerife, Canary Islands, Spain.
  • Jiménez IA; Instituto Universitario De Enfermedades Tropicales Y Salud Pública De Canarias, Universidad De La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Islas Canarias, Spain.
  • Piñero JE; Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva Y Salud Pública, Toxicología, Medicina Legal Y Forense Y Parasitología, Universidad De La Laguna, La Laguna, Tenerife, Spain.
  • Lorenzo-Morales J; Red de Investigación Cooperativa en Enfermedades Tropicales (RICET), Madrid, Spain.
  • Weaver LK; Instituto Universitario De Enfermedades Tropicales Y Salud Pública De Canarias, Universidad De La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203, La Laguna, Tenerife, Islas Canarias, Spain.
Parasitol Res ; 120(8): 3001-3005, 2021 Aug.
Article in En | MEDLINE | ID: mdl-34251514
ABSTRACT
Efficacious treatments against Acanthamoeba Keratitis (AK) is challenging, often ineffective and linked to the intragenotype variation in the drug efficacy. Increased oxygen can facilitate host response and can inhibit some organisms. Herein, we report the effect of increased oxygen concentrations on Acanthamoeba spp. growth and its effect on ROS (reactive oxygen species) production. The exposition to pure oxygen could reduce cell growth by at least 60% for Acanthamoeba castellanii Neff, Acanthamoeba polyphaga, and Acanthamoeba griffini. The increase in ROS production confirming that oxygen cell's growth inhibition was due to oxidative stress. Further studies are needed to determine oxygen saturation level, time of oxygen exposition, and number of sessions needed to eliminate the parasite.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxidative Stress / Acanthamoeba castellanii Language: En Journal: Parasitol Res Journal subject: PARASITOLOGIA Year: 2021 Document type: Article Affiliation country: España
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxidative Stress / Acanthamoeba castellanii Language: En Journal: Parasitol Res Journal subject: PARASITOLOGIA Year: 2021 Document type: Article Affiliation country: España