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Genetic mapping and phenotypic analysis of shotH.3.2 in Drosophila melanogaster.
Talley, Elyse M; Watts, Charlie T; Aboyer, Sonia; Adamson, Madeline G; Akoto, Harriet Ab; Altemus, Haley; Avella, Philip J; Bailey, Rebecca; Bell, Elizabeth R; Bell, Katheryn L; Breneman, Kelsey; Burkhart, Jessica S; Chanley, Logan J; Cook, Savannah S; DesLaurier, Mackenzie T; Dorsey, Timothy R; Doyle, Cassandra J; Egloff, Merris E; Fasawe, Ayoola S; Garcia, Katy K; Graves, Nathaniel P; Gray, Tyler K; Gustafson, Evan M; Hall, Makayla J; Hayes, Jaden D; Holic, Lindsay J; Jarvis, Brice A; Klos, Piotr S; Kritzmire, Sidney; Kuzovko, Lera; Lainez, Edwyna; McCoy, Shamerra; Mierendorf, James C; Neri, Nicole A; Neville, Caley R; Osborn, Kelley; Parker, Kaitlyn; Parks, Megan E; Peck, Kylee; Pitt, Robyn; Platta, Matthew E; Powell, Brianna; Rodriguez, Katalina; Ruiz, Clara; Schaefer, Mariah N; Shields, Amanda B; Smiley, Jasmine B; Stauffer, Briona; Straub, Devan; Sweeney, John L.
Affiliation
  • Talley EM; University of Evansville, Evansville, IN USA.
  • Watts CT; University of Evansville, Evansville, IN USA.
  • Aboyer S; Illinois State University, Normal, IL USA.
  • Adamson MG; University of Evansville, Evansville, IN USA.
  • Akoto HA; Illinois State University, Normal, IL USA.
  • Altemus H; Frostburg State University, Frostburg, MD USA.
  • Avella PJ; Illinois State University, Normal, IL USA.
  • Bailey R; University of Evansville, Evansville, IN USA.
  • Bell ER; University of Evansville, Evansville, IN USA.
  • Bell KL; University of Evansville, Evansville, IN USA.
  • Breneman K; University of Evansville, Evansville, IN USA.
  • Burkhart JS; Illinois State University, Normal, IL USA.
  • Chanley LJ; University of Evansville, Evansville, IN USA.
  • Cook SS; University of Evansville, Evansville, IN USA.
  • DesLaurier MT; Illinois State University, Normal, IL USA.
  • Dorsey TR; Illinois State University, Normal, IL USA.
  • Doyle CJ; University of Evansville, Evansville, IN USA.
  • Egloff ME; University of Evansville, Evansville, IN USA.
  • Fasawe AS; Illinois State University, Normal, IL USA.
  • Garcia KK; Frostburg State University, Frostburg, MD USA.
  • Graves NP; Frostburg State University, Frostburg, MD USA.
  • Gray TK; Illinois State University, Normal, IL USA.
  • Gustafson EM; Illinois State University, Normal, IL USA.
  • Hall MJ; Illinois State University, Normal, IL USA.
  • Hayes JD; University of Evansville, Evansville, IN USA.
  • Holic LJ; Illinois State University, Normal, IL USA.
  • Jarvis BA; Illinois State University, Normal, IL USA.
  • Klos PS; Illinois State University, Normal, IL USA.
  • Kritzmire S; University of Evansville, Evansville, IN USA.
  • Kuzovko L; Illinois State University, Normal, IL USA.
  • Lainez E; Frostburg State University, Frostburg, MD USA.
  • McCoy S; Frostburg State University, Frostburg, MD USA.
  • Mierendorf JC; Illinois State University, Normal, IL USA.
  • Neri NA; Illinois State University, Normal, IL USA.
  • Neville CR; Frostburg State University, Frostburg, MD USA.
  • Osborn K; Illinois State University, Normal, IL USA.
  • Parker K; Frostburg State University, Frostburg, MD USA.
  • Parks ME; Illinois State University, Normal, IL USA.
  • Peck K; University of Evansville, Evansville, IN USA.
  • Pitt R; Illinois State University, Normal, IL USA.
  • Platta ME; Illinois State University, Normal, IL USA.
  • Powell B; Frostburg State University, Frostburg, MD USA.
  • Rodriguez K; University of Evansville, Evansville, IN USA.
  • Ruiz C; Illinois State University, Normal, IL USA.
  • Schaefer MN; University of Evansville, Evansville, IN USA.
  • Shields AB; University of Evansville, Evansville, IN USA.
  • Smiley JB; Frostburg State University, Frostburg, MD USA.
  • Stauffer B; Frostburg State University, Frostburg, MD USA.
  • Straub D; University of Evansville, Evansville, IN USA.
  • Sweeney JL; Frostburg State University, Frostburg, MD USA.
MicroPubl Biol ; 20212021.
Article in En | MEDLINE | ID: mdl-34278244
ABSTRACT
Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2, was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. H.3.2 was found to have a nonsense mutation in short stop (shot), anortholog of the mammalian spectraplakin dystonin (DST). shot and DST are involved in cytoskeletal organization and play roles during cell growth and proliferation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: MicroPubl Biol Year: 2021 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: MicroPubl Biol Year: 2021 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA