The Roles of Cytoplasmic Lipid Droplets in Modulating Intestinal Uptake of Dietary Fat.
Annu Rev Nutr
; 41: 79-104, 2021 10 11.
Article
in En
| MEDLINE
| ID: mdl-34283920
ABSTRACT
Dietary fat absorption is required for health but also contributes to hyperlipidemia and metabolic disease when dysregulated. One step in the process of dietary fat absorption is the formation of cytoplasmic lipid droplets (CLDs) in small intestinal enterocytes; these CLDs serve as dynamic triacylglycerol storage organelles that influence the rate at which dietary fat is absorbed. Recent studies have uncovered novel factors regulating enterocyte CLD metabolism that in turn influence the absorption of dietary fat. These include peroxisome proliferator-activated receptor α activation, compartmentalization of different lipid pools, the gut microbiome, liver X receptor and farnesoid X receptor activation, obesity, and physiological factors stimulating CLD mobilization. Understanding how enterocyte CLD metabolism is regulated is key in modulating the absorption of dietary fat in the prevention of hyperlipidemia and its associated metabolic disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Fats
/
Lipid Droplets
Limits:
Humans
Language:
En
Journal:
Annu Rev Nutr
Year:
2021
Document type:
Article