The histamine H1 receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.
Clin Neurophysiol
; 132(9): 2054-2061, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34284240
ABSTRACT
OBJECTIVE:
The aim of this study was to determine the anesthesia-promoting effects of hydroxyzine on electroencephalograms during sevoflurane anesthesia and during propofol anesthesia.METHODS:
We analyzed 40 patients scheduled for elective surgery under sevoflurane anesthesia (nâ¯=â¯20) or propofol anesthesia (nâ¯=â¯20). Anesthesia was adjusted at a bispectral index value of 50-60, and then 0.5â¯mg/kg of hydroxyzine was administered intravenously. We analyzed frontal electroencephalograms before and after hydroxyzine injection with power spectral and bicoherence analyses, which are suitable for assessing the anesthetic depth induced by γ-aminobutyric acid (GABA)ergic anesthetics.RESULTS:
Hydroxyzine increased the α bicoherence peaks in both sevoflurane anesthesia (mean difference, 11.2%; 95% confidence interval (CI), 7.6 to 14.8; Pâ¯<â¯0.001) and propofol anesthesia (mean difference, 5.6%; 95% CI, 1.7 to 9.4; Pâ¯=â¯0.008). Hydroxyzine increased the averaged δ bicoherence values in both sevoflurane anesthesia (mean difference, 5.5%; 95% CI, 2.1 to 8.8; Pâ¯=â¯0.003) and propofol anesthesia (mean difference, 3.9%; 95% CI, 1.0 to 6.8; Pâ¯=â¯0.011).CONCLUSIONS:
Hydroxyzine enhances both sevoflurane anesthesia and propofol anesthesia probably by facilitation of GABAergic neural circuit mechanisms.SIGNIFICANCE:
The findings provide a new insight into the role of histaminergic neurons during general anesthesia in humans.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propofol
/
Electroencephalography
/
Sevoflurane
/
Histamine H1 Antagonists
/
Hydroxyzine
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2021
Document type:
Article
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS