Radical Annulation of 2-Cyanoaryl Acrylamides via CâC Double Bond Cleavage: Access to Amino-Substituted 2-Quinolones.
Org Lett
; 23(15): 6158-6163, 2021 Aug 06.
Article
in En
| MEDLINE
| ID: mdl-34313448
ABSTRACT
A novel annulation of 2-cyanoaryl acrylamides via CâC double bond cleavage has been developed for facile and efficient access to a broad spectrum of functionalized 4-amino-2-quinolones, which are important N-heterocycles. In this transformation, the solvent THF is demonstrated to play a crucial role, and the addition of alkyl radicals to nitrile, 1,5-hydride shift, and cleavage of the C-C bond are involved in the mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2021
Document type:
Article