International Multicenter Validation Study of the SAGIT® Instrument in Acromegaly.
J Clin Endocrinol Metab
; 106(12): 3555-3568, 2021 11 19.
Article
in En
| MEDLINE
| ID: mdl-34313752
ABSTRACT
CONTEXT The SAGIT® instrument (SAGIT) has been developed to enable accurate characterization of acromegaly disease activity. OBJECTIVE:
We evaluated the ability of SAGIT to discriminate acromegaly disease control status.METHODS:
This multicenter, noninterventional, prospective and retrospective, longitudinal study, conducted at academic and private clinical practice sites, included patients agedâ ≥â 18 years with a diagnosis of controlled (nâ =â 109) or non-controlled (nâ =â 105) acromegaly, assessed by clinical global evaluation of disease control (CGE-DC) questionnaire, investigator therapeutic decision, and international guidelines. Control status was not determined at baseline for 13 patients. Since 9 patients were enrolled retrospectively, all presented analyses are based on the prospective population (Nâ =â 227). Patients were assessed over a 2-year follow-up period. Classification and regression tree (CART) analyses were performed to investigate how SAGIT components at baseline (signs/symptoms [S], associated comorbidities [A], growth hormone levels [G], insulin-like growth factor 1 levels [I], tumor features [T]) discriminate between controlled and non-controlled acromegaly.RESULTS:
Baseline mean subscores S, G, I, and T were significantly lower in patients with CGE-DC controlled vs CGE-DC non-controlled acromegaly. SAGIT components I and G for CGE-DC and S, A, G, I, and T for the clinician's therapeutic decision were retained by CART analyses. For international guidelines, only SAGIT component I was retained. The risk for undergoing ≥ 1 treatment change during the study was 3.44 times greater for CGE-DC non-controlled acromegaly relative to CGE-DC controlled acromegaly.CONCLUSION:
The SAGIT instrument is a valid and sensitive tool to comprehensively and accurately assess acromegaly severity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acromegaly
/
Insulin-Like Growth Factor I
/
Biomarkers
/
Human Growth Hormone
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Diagnostic Tests, Routine
Type of study:
Guideline
/
Observational_studies
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Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limits:
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2021
Document type:
Article
Affiliation country:
Italia