High-dose medroxyprogesterone in disseminated breast cancer. Correlation between bioavailability and clinical response.
Tumori
; 73(6): 617-21, 1987 Dec 31.
Article
in En
| MEDLINE
| ID: mdl-3433369
Clinical response to high-dose medroxyprogesterone (MPA), administered following three different routes of administration (i.m., p.o. + i.m., p.o.) and monitoring drug plasma levels, was evaluated in pretreated advanced breast cancer patients. Fifty-eight of 68 eligible patients were considered evaluable for response. Age ranged between 36 years and 82 years. Fifty-six of 58 evaluable patients were postmenopausal. An overall remission rate of 48% was achieved with i.m. MPA, 50% with combined (i.m. + p.o.) modalities; only a 19% remission rate was recorded in the p.o. group. Response rate and MPA plasma concentrations were correlated, and a drug level of 80 ng/ml, by means of a GLC method, seems to identify a subset of patients with high probability of response. Only mild toxic effects were recorded.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Medroxyprogesterone
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Tumori
Year:
1987
Document type:
Article
Affiliation country:
Italia
Country of publication:
Estados Unidos