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RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-ß signaling in cancer.
Tian, En-Ming; Yu, Ming-Cheng; Feng, Mei; Lu, Li-Xue; Liu, Cheng-Long; Shen, Li-An; Wang, Yong-Hui; Xie, Qiong; Zhu, Di.
Affiliation
  • Tian EM; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Yu MC; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Feng M; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Lu LX; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Liu CL; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Shen LA; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Wang YH; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: qxie@fudan.edu.cn.
  • Zhu D; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China; School of Basic Medical Sciences, Fudan Unvieristy, Shanghai 200032, China. Electronic address: zhudi@fudan.edu.cn.
Pharmacol Res ; 172: 105793, 2021 10.
Article in En | MEDLINE | ID: mdl-34339836
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Receptor Subfamily 1, Group F, Member 3 / CTLA-4 Antigen / Antibodies / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: Países Bajos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Receptor Subfamily 1, Group F, Member 3 / CTLA-4 Antigen / Antibodies / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: Países Bajos