Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives.
Biomolecules
; 11(7)2021 07 11.
Article
in En
| MEDLINE
| ID: mdl-34356639
ABSTRACT
Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Peroxidase
/
Nanostructures
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomolecules
Year:
2021
Document type:
Article
Affiliation country:
Taiwán