Cost effectiveness of three months of rifapentine and isoniazid for latent tuberculosis in Syrian refugees.
J Clin Tuberc Other Mycobact Dis
; 24: 100262, 2021 Aug.
Article
in En
| MEDLINE
| ID: mdl-34368467
ABSTRACT
BACKGROUND:
Latent Tuberculosis infection (LTBI) has a large global burden especially among refugees. We aimed to test the cost effectiveness of weekly rifapentine plus isoniazid for 3 months (3HP) versus nine months of daily isoniazid (INH-9) to treat LTBI in Syrian refugees residing in Turkey.METHODS:
We used a Markov state transition model to estimate the incremental cost-effectiveness of 3HP relative to INH-9 using a simulated cohort of Syrian refugees. Both cost and effectiveness were assessed assuming that LTBI screening would be performed, with treatment of those who screen positive. Costs were measured in 2017 US dollars, and effectiveness was estimated as quality adjusted life years (QALYs) gained. An annual discount rate of 3% was applied to future costs and QALYs over the analytical time horizon of 20 years.RESULTS:
Per 100 individuals screened at age 30 in the base case scenario, treating LTBI with 3HP rather than INH-9 resulted in a gain of 0.08 QALYs (95% uncertainty interval -0.007, 0.221) and savings of $1421 ($483, $3478). Assuming a value of $100000 per QALY, the incremental net monetary benefit of 3HP was $9772 ($639, $24517). Findings were robust to sensitivity analyses except when treating older individuals.CONCLUSIONS:
3HP is likely to save costs and improve health compared to INH-9 when used for LTBI treatment among Syrian refugees in Turkey.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Health_economic_evaluation
/
Prognostic_studies
Aspects:
Patient_preference
Language:
En
Journal:
J Clin Tuberc Other Mycobact Dis
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos