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High glycosyltransferase 8 domain containing two protein levels contribute to poor prognosis in urothelial carcinoma.
Chen, Tzu-Ju; Chan, Ti-Chun; Li, Chien-Feng; Dilshan Sampath Dissanayaka, Dissanayakage; Kianpour, Maryam; He, Hong-Lin; Huang, Steven K; Li, Wan-Shan; Chen, Nai-Yu; Shiue, Yow-Ling.
Affiliation
  • Chen TJ; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
  • Chan TC; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
  • Li CF; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan.
  • Dilshan Sampath Dissanayaka D; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
  • Kianpour M; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
  • He HL; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
  • Huang SK; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
  • Li WS; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
  • Chen NY; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan.
  • Shiue YL; Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Int J Urol ; 28(11): 1178-1187, 2021 11.
Article in En | MEDLINE | ID: mdl-34374132
ABSTRACT

OBJECTIVE:

To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients.

METHODS:

Data mining, immunohistochemistry together with H-score calculation was carried out to evaluate the glycosyltransferase 8 domain containing protein 2 levels on tissue specimens from urothelial carcinoma patients, retrospectively. Correlations between glycosyltransferase 8 domain containing protein 2 H-score and imperative clinicopathological factors were measured. The indication of glycosyltransferase 8 domain containing protein 2 level on disease-specific and metastasis-free survivals were next analyzed.

RESULTS:

In upper tract urothelial carcinomas (n = 340) and bladder urothelial carcinomas (n = 295), 170 (50%) and 148 (50%) patients, respectively, were identified to have high glycosyltransferase 8 domain containing protein 2 expression. The glycosyltransferase 8 domain containing protein 2 levels were correlated to several clinicopathological characteristics and patient survival. Upregulation of the glycosyltransferase 8 domain containing protein 2 was correlated to primary tumor (P < 0.001), nodal metastasis (P < 0.001), histological grade (P < 0.001), vascular invasion (P < 0.001), perineural invasion (P < 0.05) and mitotic rate (P < 0.001). High glycosyltransferase 8 domain containing protein 2 levels independently predicted poor disease-specific survival (P = 0.049) and metastasis-free survival (P = 0.008) in upper tract urothelial carcinoma and urinary bladder urothelial carcinoma, respectively. Gene Ontology enrichment analysis additionally showed that multiple biological processes were enriched including "ECM organization" (Gene Ontology0030198), "extracellular structure organization" (Gene Ontology0043062), "biological adhesion" (Gene Ontology0022610), "cell adhesion" (Gene Ontology0007155), "collagen fibril organization" (Gene Ontology0030199) and "vasculature development" (Gene Ontology0001944).

CONCLUSIONS:

The present findings suggest that upregulation of the glycosyltransferase 8 domain containing protein 2 is an independent and disadvantageous prognosticator in urothelial carcinoma. High glycosyltransferase 8 domain containing protein 2 level might play a crucial role in progression of urothelial carcinoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Glycosyltransferases Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Int J Urol Journal subject: UROLOGIA Year: 2021 Document type: Article Affiliation country: Taiwán

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Glycosyltransferases Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Int J Urol Journal subject: UROLOGIA Year: 2021 Document type: Article Affiliation country: Taiwán