Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes.

Miller, Adriana; Matera-Witkiewicz, Agnieszka; Mikolajczyk, Aleksandra; Wieczorek, Robert; Rowinska-Zyrek, Magdalena

Miller, Adriana; Matera-Witkiewicz, Agnieszka; Mikolajczyk, Aleksandra; Wieczorek, Robert; Rowinska-Zyrek, Magdalena.

Affiliation

Miller A; Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.
Matera-Witkiewicz A; Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Mikolajczyk A; Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Wieczorek R; Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.
Rowinska-Zyrek M; Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.

Inorg Chem ; 60(17): 12730-12734, 2021 Sep 06.

Article in En | MEDLINE | ID: mdl-34382773

ABSTRACT

Can a minor difference in the nonmetal binding sequence of antimicrobial clavanins explain the drastic change in the coordination environment and antimicrobial efficiency? This study answers the question with a definite "yes", showing the details of the bioinorganic chemistry of Zn(II) and Cu(II) complexes with clavanins, histidine-rich, antimicrobial peptides from hemocytes of the tunicate Styela clava.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Proteins / Coordination Complexes / Anti-Bacterial Agents Limits: Humans Language: En Journal: Inorg Chem Year: 2021 Document type: Article Affiliation country: Polonia Country of publication: Estados Unidos

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