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High G protein subunit beta 4 protein level is correlated to poor prognosis of urothelial carcinoma.
Chen, Tzu-Ju; Dehghanian, Seyedeh Zahra; Chan, Ti-Chun; He, Hong-Lin; Li, Wan-Shan; Abdollahi, Sina; Chen, Nai-Yu; Li, Chien-Feng; Shiue, Yow-Ling.
Affiliation
  • Chen TJ; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
  • Dehghanian SZ; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan.
  • Chan TC; Institute of Biomedical Sciences, National Sun Yat-Sen University, 70 Lienhai Rd., 80424, Kaohsiung, Taiwan.
  • He HL; Institute of Biomedical Sciences, National Sun Yat-Sen University, 70 Lienhai Rd., 80424, Kaohsiung, Taiwan.
  • Li WS; Department of Medical Research, Chi Mei Medical Center, 901 Zhanghua Rd, 71004, Tainan, Taiwan.
  • Abdollahi S; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
  • Chen NY; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
  • Li CF; Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan.
  • Shiue YL; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan.
Med Mol Morphol ; 54(4): 356-367, 2021 Dec.
Article in En | MEDLINE | ID: mdl-34398348
ABSTRACT
Data mining on a public domain detected eight potential transcripts which were upregulated in advanced UBUCs, suggesting that they may take part in UC development or/and progression. Retrospectively, immunohistochemistry along with H-score recording was carried out to evaluate the GNB4 protein levels on tissues from UC patients. Correlations between GNB4 H-score and imperative clinicopathological factors, as well as the implication of GNB4 protein level on disease-specific and metastasis-free survivals were assessed. In UTUCs (n = 340) and UBUCs (n = 295), 170 (50.0%) and 148 (50.0%) cases, respectively, were identified to be of high GNB4 expression. The GNB4 protein levels were correlated to numerous clinicopathological features and patients' survivals. Upregulation of the GNB4 protein was significantly associated with primary tumor, nodal metastasis, histological grade, vascular invasion and mitotic rate. High GNB4 protein levels independently and significantly predicted poor disease-specific and metastasis-free in UTUC and UBUC, respectively. Ingenuity pathway analysis furthermore showed that multiple signaling pathways were enriched including 'Communication between Innate and Adaptive Immune Cells' and 'NFκB Signaling'. Our findings demonstrated that the upregulation of the GNB4 protein is an independent unfavorable prognosticator in UC. High GNB4 gene expression plays an important role in UC progression.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / GTP-Binding Protein beta Subunits Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Med Mol Morphol Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2021 Document type: Article Affiliation country: Taiwán

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / GTP-Binding Protein beta Subunits Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Med Mol Morphol Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2021 Document type: Article Affiliation country: Taiwán