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High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer.
Zhu, Liang; Pan, Jia-Ni; Qian, Ziliang; Ye, Wei-Wu; Wang, Xiao-Jia; Cao, Wen-Ming.
Affiliation
  • Zhu L; Department of Pathology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, China.
  • Pan JN; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, 310022, China.
  • Qian Z; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, 310022, China.
  • Ye WW; Department of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, China.
  • Wang XJ; Zhejiang Chinese Medical University, Hangzhou, 310053, China.
  • Cao WM; Prophet Genomics Inc, San Jose, CA, 95131, USA.
Breast Cancer ; 29(1): 103-113, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34403063
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Tumor Suppressor Protein p53 / Germ-Line Mutation / Gene Dosage / BRCA1 Protein / Chromosomal Instability Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Breast Cancer Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country: China Country of publication: Japón
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Tumor Suppressor Protein p53 / Germ-Line Mutation / Gene Dosage / BRCA1 Protein / Chromosomal Instability Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Breast Cancer Journal subject: NEOPLASIAS Year: 2022 Document type: Article Affiliation country: China Country of publication: Japón