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Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.
Nolan, Laura M; Cain, Amy K; Clamens, Thomas; Furniss, R Christopher D; Manoli, Eleni; Sainz-Polo, Maria A; Dougan, Gordon; Albesa-Jové, David; Parkhill, Julian; Mavridou, Despoina A I; Filloux, Alain.
Affiliation
  • Nolan LM; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
  • Cain AK; National Heart and Lung Institute, Imperial College London, London, UK.
  • Clamens T; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Furniss RCD; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
  • Manoli E; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
  • Sainz-Polo MA; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
  • Dougan G; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • Albesa-Jové D; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
  • Parkhill J; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
  • Mavridou DAI; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  • Filloux A; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
Nat Microbiol ; 6(9): 1199-1210, 2021 09.
Article in En | MEDLINE | ID: mdl-34413503
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Bacterial Proteins / Bacterial Toxins / Protein Biosynthesis / Multiprotein Complexes / Type VI Secretion Systems Type of study: Diagnostic_studies Language: En Journal: Nat Microbiol Year: 2021 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Bacterial Proteins / Bacterial Toxins / Protein Biosynthesis / Multiprotein Complexes / Type VI Secretion Systems Type of study: Diagnostic_studies Language: En Journal: Nat Microbiol Year: 2021 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido