Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA.
Int J Cardiol
; 340: 26-33, 2021 10 01.
Article
in En
| MEDLINE
| ID: mdl-34437934
ABSTRACT
BACKGROUND:
There is conflicting observational data on the survival benefit cardiac implantable electronic devices (CIED) in patients with LVADs.METHODS:
Patients in whom an LVAD was implanted between January 2008 and April 2017 in the multinational Trans-Atlantic Registry on VAD and Transplant (TRAViATA) registry were separated into four groups based on the presence of CIED prior to LVAD implantation none (n = 146), implantable cardiac defibrillator (ICD) (n = 239), cardiac resynchronization without defibrillator (CRT-P) (n = 28), and CRT with defibrillator (CRT-D) (n = 111).RESULTS:
A total of 524 patients (age 52 years ±12, 84.4% male) were followed for 354 (interquartile range 166-701) days. After multivariable adjustment, there were no differences in survival across the groups. In comparison to no device, only CRT-D was associated with late right ventricular failure (RVF) (hazard ratio 2.85, 95% confidence interval [CI] 1.42-5.72, p = 0.003). There was no difference in risk of early RVF across the groups or risk of ICD shocks between those with ICD and CRT-D.CONCLUSION:
In a multinational registry of patients with LVADs, there were no differences in survival with respect to CIED subtype. However, patients with a pre-existing CRT-D had a higher likelihood of late RVF suggesting significant long-term morbidity in those with devices capable of LVlead pacing post LVAD implantation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart-Assist Devices
/
Defibrillators, Implantable
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Cardiac Resynchronization Therapy
/
Heart Failure
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Cardiol
Year:
2021
Document type:
Article