Anticancer Effect of Rh2, a Histone Deacetylase Inhibitor, in HepG2 Cells and HepG2 Cell-Derived Xenograft Tumors Occurs via the Inhibition of HDACs and Activation of the MAPK Signaling Pathway.

Qiang, Shi Qing; Qin, Gao Chao; Jing, Li; Qiang, Feng Zi; Mei, Qin Hong; Long, Chen Di

Qiang, Shi Qing; Qin, Gao Chao; Jing, Li; Qiang, Feng Zi; Mei, Qin Hong; Long, Chen Di.

Affiliation

Qiang SQ; The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Qin GC; Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.
Jing L; Department of Pharmacy, Renhe Community Health Service Center of Chongqing Liangjiang New Area, Chongqing, China.
Qiang FZ; Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.
Mei QH; Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.
Long CD; The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, China.

Asian Pac J Cancer Prev ; 22(8): 2529-2539, 2021 Aug 01.

Article in En | MEDLINE | ID: mdl-34452568

Subject(s)
Key words

20(S)-ginsenoside Rh2; HepG2 cells; MAPK; histone deacetylase; hypoxia-inducible factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Carcinoma, Hepatocellular / MAP Kinase Signaling System / Ginsenosides / Histone Deacetylase Inhibitors / Histone Deacetylases / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Asian Pac J Cancer Prev Journal subject: NEOPLASIAS Year: 2021 Document type: Article Country of publication: Tailandia

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