Ferritin H can counteract inflammatory response in hybrid fish and its parental species after Aeromonas hydrophila infection.
Comp Biochem Physiol C Toxicol Pharmacol
; 250: 109174, 2021 Dec.
Article
in En
| MEDLINE
| ID: mdl-34461291
ABSTRACT
Ferritin H can participate in the regulation of fish immunity. Tissue-specific analysis revealed that the highest expressions of Ferritin H in parental species were observed in spleen, while peaked level of Ferritin H mRNA in hybrid fish was observed in liver. In addition, A. hydrophila challenge could sharply enhance their Ferritin H mRNA expression in liver, kidney and spleen. To further investigate their roles in immune regulation, their Ferritin H fusion proteins were produced in vitro. Ferritin H fusion proteins could exhibit a direct binding activity to A. hydrophila and endotoxin in a dose-dependent manner, restrict dissemination of A. hydrophila to tissues and abrogate inflammatory cascades. Moreover, treatment with Ferritin H fusion proteins could reduce A. hydrophila-induced lipid peroxidation. These results indicated that Ferritin H in hybrid fish elicited a similar immune regulation of A. hydrophila-induced inflammatory signals in comparison with those of its parents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apoferritins
/
Carps
/
Fish Proteins
/
Fish Diseases
Limits:
Animals
Language:
En
Journal:
Comp Biochem Physiol C Toxicol Pharmacol
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2021
Document type:
Article