Surgical treatment for squamous cell carcinoma of the temporal bone: predictors of survival.
Acta Otorhinolaryngol Ital
; 41(4): 308-316, 2021 Aug.
Article
in En
| MEDLINE
| ID: mdl-34533534
ABSTRACT
OBJECTIVE:
Evaluation of the management and survival in patients treated for temporal bone squamous cell carcinoma (TBSCC) in a tertiary referral centre.METHODS:
Forty-nine patients underwent primary treatment for TBSCC. Thirty-six patients underwent a lateral temporal bone resection (LTBR) or subtotal temporal bone resection (STBR). Overall survival (OS) and disease-specific survival (DSS) analysis were assessed.RESULTS:
Five-year OS of the 49 patients was 39%. Five-year OS of the 36 patients who underwent LTBR or STBR was 46%. Tumour-free margins were achieved in all patients with T1 and T2 disease, in 59% patients with T3 tumours and 0% patients with T4 disease. Five-year DSS was 85% for all T1/T2 tumours, 53% for T3 tumours and 0% for T4 tumours. Clear resection margins was the only significant predictor of DSS in our cohort.CONCLUSIONS:
The mainstay of treatment for TBSCC is temporal bone resection with tumour free resection margins, with or without adjuvant radiotherapy. Survival is negatively influenced by non-radical resection. T1 and T2 tumours can be managed safely with LTBR. More advanced disease requires a more extensive resection, with a higher likelihood of non-radical resections and decreased survival rates.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Temporal Bone
/
Carcinoma, Squamous Cell
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Acta Otorhinolaryngol Ital
Year:
2021
Document type:
Article
Affiliation country:
Países Bajos