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Surgical treatment for squamous cell carcinoma of the temporal bone: predictors of survival.
Smit, Conrad F; de Boer, Niels; Lissenberg-Witte, Birgit I; Merkus, Paul; Hensen, Erik F; Leemans, C René.
Affiliation
  • Smit CF; Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.
  • de Boer N; Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.
  • Lissenberg-Witte BI; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.
  • Merkus P; Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.
  • Hensen EF; Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.
  • Leemans CR; Department of Otolaryngology & Head and Neck Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
Acta Otorhinolaryngol Ital ; 41(4): 308-316, 2021 Aug.
Article in En | MEDLINE | ID: mdl-34533534
ABSTRACT

OBJECTIVE:

Evaluation of the management and survival in patients treated for temporal bone squamous cell carcinoma (TBSCC) in a tertiary referral centre.

METHODS:

Forty-nine patients underwent primary treatment for TBSCC. Thirty-six patients underwent a lateral temporal bone resection (LTBR) or subtotal temporal bone resection (STBR). Overall survival (OS) and disease-specific survival (DSS) analysis were assessed.

RESULTS:

Five-year OS of the 49 patients was 39%. Five-year OS of the 36 patients who underwent LTBR or STBR was 46%. Tumour-free margins were achieved in all patients with T1 and T2 disease, in 59% patients with T3 tumours and 0% patients with T4 disease. Five-year DSS was 85% for all T1/T2 tumours, 53% for T3 tumours and 0% for T4 tumours. Clear resection margins was the only significant predictor of DSS in our cohort.

CONCLUSIONS:

The mainstay of treatment for TBSCC is temporal bone resection with tumour free resection margins, with or without adjuvant radiotherapy. Survival is negatively influenced by non-radical resection. T1 and T2 tumours can be managed safely with LTBR. More advanced disease requires a more extensive resection, with a higher likelihood of non-radical resections and decreased survival rates.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Temporal Bone / Carcinoma, Squamous Cell Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Acta Otorhinolaryngol Ital Year: 2021 Document type: Article Affiliation country: Países Bajos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Temporal Bone / Carcinoma, Squamous Cell Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Acta Otorhinolaryngol Ital Year: 2021 Document type: Article Affiliation country: Países Bajos