Combined Preconditioning Reduces the Negative Influence of Cerebral Ischemia on the Morphofunctional Condition of CNS.
Bull Exp Biol Med
; 171(4): 489-493, 2021 Aug.
Article
in En
| MEDLINE
| ID: mdl-34542765
ABSTRACT
We studied the influence of combined preconditioning (compound pQ-4 and moderate hypoxia) on morphometrical parameters of neuronal populations in hippocampal fields CA1 and CA3 in rats after bilateral ligation of the common carotid artery. Preconditioning produced a neuroprotective effect, improved survival of pyramidal neurons in the early and delayed periods of modeled ischemia, prevented the formation of necrotic and apoptotic neurons and hyperactivation of microglia, and protected endotheliocytes. The positive influence of preconditioning factors on the morphometric parameters of the brain under ischemic conditions agrees with the results of behavioral tests (open field and elevated plus maze) that demonstrated increased locomotor activity and exploratory behavior of animals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Cerebral Infarction
/
Brain Ischemia
/
Ischemic Preconditioning
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2021
Document type:
Article
Affiliation country:
Rusia