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Neurodevelopmental malformations of the cerebellum and neocortex in the Shank3 and Cntnap2 mouse models of autism.
Otazu, Gonzalo H; Li, Yan; Lodato, Zachary; Elnasher, Adel; Keever, Katherine M; Li, Ying; Ramos, Raddy L.
Affiliation
  • Otazu GH; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Li Y; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Lodato Z; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Elnasher A; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Keever KM; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Li Y; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States.
  • Ramos RL; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, United States. Electronic address: rramos02@nyit.edu.
Neurosci Lett ; 765: 136257, 2021 11 20.
Article in En | MEDLINE | ID: mdl-34555490
ABSTRACT
There are many mouse models of autism with broad use in neuroscience research. Genetic background can be a major contributor to the phenotype observed in any mouse model of disease, including genetic models of autism. C57BL/6 mice display spontaneous glio-neuronal heterotopia in the cerebellar vermis and neocortex which may also exist in mouse models of autism created on this background. In the present report, we document the presence of cerebellar and neocortical heterotopia in heterozygous and KO Shank3 and Cntnap2 mice which are due to the C57BL/6 genotype and discuss the role these malformations may play in research using these genetic models of autism.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Disease Models, Animal / Malformations of Cortical Development, Group II / Membrane Proteins / Microfilament Proteins / Nerve Tissue Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Neurosci Lett Year: 2021 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Disease Models, Animal / Malformations of Cortical Development, Group II / Membrane Proteins / Microfilament Proteins / Nerve Tissue Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Neurosci Lett Year: 2021 Document type: Article Affiliation country: Estados Unidos