Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes.

Watanabe, Daisuke; Nakagawa, Shinsuke; Morofuji, Yoichi; Tóth, Andrea E; Vastag, Monika; Aruga, Jun; Niwa, Masami; Deli, Mária A

Watanabe, Daisuke; Nakagawa, Shinsuke; Morofuji, Yoichi; Tóth, Andrea E; Vastag, Monika; Aruga, Jun; Niwa, Masami; Deli, Mária A.

Affiliation

Watanabe D; Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Nakagawa S; BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki 852-8135, Japan.
Morofuji Y; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Tóth AE; Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Vastag M; Institute of Biophysics, Biological Research Centre, Temesvári krt. 62, H-6726 Szeged, Hungary.
Aruga J; In Vitro Metabolism Research, Division of Pharmacology and Drug Safety Research, Gedeon Richter Plc., Gyömroi út 19-21, H-1103 Budapest, Hungary.
Niwa M; Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Deli MA; BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki 852-8135, Japan.

Pharmaceutics ; 13(9)2021 Sep 16.

Article in En | MEDLINE | ID: mdl-34575559

Key words

astrocyte; blood-brain barrier; brain endothelial cell; co-culture; drug permeability; pericyte; transendothelial electrical resistance; transporter

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Pharmaceutics Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Suiza

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