Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti.
Future Med Chem
; 13(22): 2015-2025, 2021 11.
Article
in En
| MEDLINE
| ID: mdl-34590494
ABSTRACT
The mosquito continues to be the most lethal animal to humans due to the devastating diseases that it carries and transmits. Controlling mosquito-borne diseases relies heavily on vector management using neurotoxic insecticides with limited modes of action. This has led to the emergence of resistance to pyrethroids and other neurotoxic insecticides in mosquitoes, which has reduced the efficacy of chemical control agents. Moreover, many neurotoxic insecticides are not selective for mosquitoes and negatively impact beneficial insects such as honeybees. Developing new mosquitocides with novel mechanisms of action is a clear unmet medical need; this review covers the efforts made toward this end by targeting the renal inward rectifier potassium channel (Kir) of the mosquito.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Potassium Channels, Inwardly Rectifying
/
Mosquito Vectors
/
Insecticides
Limits:
Animals
/
Humans
Language:
En
Journal:
Future Med Chem
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos