PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance.

Feng, Chenchen; Li, Yuqing; Li, Kunping; Lyu, Yinfeng; Zhu, Wenhui; Jiang, Haowen; Wen, Hui

Feng, Chenchen; Li, Yuqing; Li, Kunping; Lyu, Yinfeng; Zhu, Wenhui; Jiang, Haowen; Wen, Hui.

Affiliation

Feng C; Department of Urology, Huashan Hospital, Fudan University, 12 Middle Urumqi Rd, 200040, Shanghai, PR China.
Li Y; Institute of Urology, Fudan University, 200040, Shanghai, PR China.
Li K; Department of Urology, Huashan Hospital, Fudan University, 12 Middle Urumqi Rd, 200040, Shanghai, PR China.
Lyu Y; Institute of Urology, Fudan University, 200040, Shanghai, PR China.
Zhu W; Department of Urology, Huashan Hospital, Fudan University, 12 Middle Urumqi Rd, 200040, Shanghai, PR China.
Jiang H; Institute of Urology, Fudan University, 200040, Shanghai, PR China.
Wen H; Department of Urology, Huashan Hospital, Fudan University, 12 Middle Urumqi Rd, 200040, Shanghai, PR China.

J Exp Clin Cancer Res ; 40(1): 308, 2021 Sep 30.

Article in En | MEDLINE | ID: mdl-34593007

Subject(s)
Key words

Clear-cell renal cell carcinoma; PFKFB4; Pentose phosphate pathway; Resistance; Sunitinib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentose Phosphate Pathway / Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Phosphofructokinase-2 / Metabolome / Sunitinib / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: J Exp Clin Cancer Res Year: 2021 Document type: Article Country of publication: Reino Unido

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