The New Generation Immunochemical Test for Fecal Occult Blood (ColonView Quick Test) Shows a High Diagnostic Accuracy in Colorectal Cancer Detection.
Anticancer Res
; 41(10): 5071-5079, 2021 Oct.
Article
in En
| MEDLINE
| ID: mdl-34593457
ABSTRACT
BACKGROUND/AIM:
The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation immunochemical test (FIT) for Hb and Hb/Hp (Biohit Oyj, Helsinki, Finland) in subjects participating in colorectal cancer (CRC) detection in Brazil. A traditional gFOBT test (HemoccultSENSA) was used as a reference. PATIENTS ANDMETHODS:
A cohort of 368 colonoscopy-referral patients were asked to collect 3 consecutive fecal samples, to be analysed by both assays (CV, SENSA).RESULTS:
In receiver operating characteristic (ROC) analysis for the AA reading, the optimal cut-off value for CV Hb AA (test AA 3) was ≥117 and that for CV Hb/Hp AA (test AA 4) was ≥48. In the hierarchical summary receiver operating characteristic (HSROC) analysis for pooled accuracy of CV with AA and VA reading, the AUC values for i) VA and ii) AA were as follows i) AUC=0.859 (95%CI=0.839-0.879), ii) AUC=0.931 (95%CI=0.920-0.942). The difference between these AUC values (Roccomp analysis) was statistically significant (p=0.0024).CONCLUSION:
The present study confirms the previous studies on the applicability of the ColonView quick test (a new-generation FIT) in CRC screening.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunochemistry
/
Colorectal Neoplasms
/
Colonoscopy
/
Early Detection of Cancer
/
Occult Blood
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
Anticancer Res
Year:
2021
Document type:
Article
Affiliation country:
Finlandia