The therapeutic role of lasers in primary localized cutaneous amyloidosis: a systematic review.
Lasers Med Sci
; 37(2): 799-813, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-34611800
ABSTRACT
With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, assessed the quality of each study, and then extracted the eligible data. Five RCTs(randomized controlled trials), one non-randomized controlled trial, three case series, and nine case reports(18 in total) were included. Overall, carbon dioxide (CO2), neodymium-dopedyttrium aluminum garnet (NdYAG), pulsed dye (PDL), Er (Erbium)YAG, and yttrium/erbium fiber were the studied lasers. One hundred fifty-five cases in total underwent laser therapy, with CO2 being the most frequent laser. Almost all studies demonstrated significantly desirable outcomes, while only mild and transient side effects were noted. Even though the studies' results were significant, we noticed that implementing a consistent methodology and a standardized objective assessment method was missing. Therefore, we recommend that future studies be conducted with less heterogeneous data for a more definite conclusion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases, Genetic
/
Amyloidosis, Familial
/
Laser Therapy
/
Lasers, Solid-State
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Lasers Med Sci
Journal subject:
BIOTECNOLOGIA
/
RADIOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Irán