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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Fowler, Stephen; Brink, Andreas; Cleary, Yumi; Günther, Andreas; Heinig, Katja; Husser, Christophe; Kletzl, Heidemarie; Kratochwil, Nicole; Mueller, Lutz; Savage, Mark; Stillhart, Cordula; Tuerck, Dietrich; Ullah, Mohammed; Umehara, Kenichi; Poirier, Agnès.
Affiliation
  • Fowler S; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Brink A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Cleary Y; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Günther A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Heinig K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Husser C; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Kletzl H; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Kratochwil N; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Mueller L; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Savage M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Stillhart C; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Tuerck D; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Ullah M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Umehara K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Poirier A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
Drug Metab Dispos ; 50(1): 65-75, 2022 01.
Article in En | MEDLINE | ID: mdl-34620695
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azo Compounds / RNA, Messenger / Pharmaceutical Preparations / Tissue Distribution / RNA Splicing Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2022 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azo Compounds / RNA, Messenger / Pharmaceutical Preparations / Tissue Distribution / RNA Splicing Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2022 Document type: Article Country of publication: Estados Unidos