Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses.
J Infect Dis
; 224(12): 2020-2024, 2021 12 15.
Article
in En
| MEDLINE
| ID: mdl-34651643
ABSTRACT
BACKGROUND:
The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood.METHODS:
In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant.RESULTS:
Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT and salivary gland tissues, which was also shared by the B.1.1.7 virus.CONCLUSIONS:
In our analyses, we highlighted the active role of these anatomic sites in coronavirus disease 2019.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory System
/
Virus Replication
/
Viral Tropism
/
COVID-19
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
2021
Document type:
Article
Affiliation country:
Alemania
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA