IGF-1 alleviates CCL4-induced hepatic cirrhosis and dysfunction of intestinal barrier through inhibition TLR4/NF-&#954;B signaling mediated by down-regulation HMGB1.

Zhao, Tianyu; Zhu, Ying; Yao, Liying; Liu, Liu; Li, Na

IGF-1 alleviates CCL4-induced hepatic cirrhosis and dysfunction of intestinal barrier through inhibition TLR4/NF-κB signaling mediated by down-regulation HMGB1.

Zhao, Tianyu; Zhu, Ying; Yao, Liying; Liu, Liu; Li, Na.

Affiliation

Zhao T; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.
Zhu Y; Integrated Traditional Chinese and Western Medicine Liver Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China. Electronic address: zhuyingsh53@126.com.
Yao L; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.
Liu L; Integrated Traditional Chinese and Western Medicine Liver Center, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.
Li N; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.

Ann Hepatol ; 26: 100560, 2021 Dec.

Article in En | MEDLINE | ID: mdl-34653689

Subject(s)
Key words

Cirrhosis; HMGB1; IGF-1; TLR4/NF-κB pathway; intestinal barrier

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Carbon Tetrachloride Poisoning / Down-Regulation / Gene Expression Regulation / HMGB1 Protein / Intestinal Mucosa / Liver Cirrhosis, Experimental Type of study: Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Ann Hepatol Journal subject: GASTROENTEROLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: México

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