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Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial.
Uccelli, Antonio; Laroni, Alice; Ali, Rehiana; Battaglia, Mario Alberto; Blinkenberg, Morten; Brundin, Lou; Clanet, Michel; Fernandez, Oscar; Marriot, James; Muraro, Paolo; Nabavi, Seyed Massood; Oliveri, Roberto S; Radue, Ernst; Ramo Tello, Cristina; Schiavetti, Irene; Sellner, Johann; Sorensen, Per Soelberg; Sormani, Maria Pia; Wuerfel, Jens Thomas; Freedman, Mark S.
Affiliation
  • Uccelli A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: auccelli@neurologia.unige.it.
  • Laroni A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Ali R; Department of Brain Sciences, Imperial College London, London, UK.
  • Battaglia MA; Department of Life Sciences, University of Siena, Italy; Italian Multiple Sclerosis Foundation, Genoa, Italy.
  • Blinkenberg M; Danish Multiple Sclerosis Centre, Department of Neurology, University of Copenhagen and Rigshospitalet, Copenhagen, Denmark.
  • Brundin L; Department of Clinical Neuroscience, Karolinska Institutet, and Division of Neurology, Karolinska University Hospital, Stockholm, Sweden.
  • Clanet M; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
  • Fernandez O; Department of Neurology, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario, Málaga, Spain.
  • Marriot J; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  • Muraro P; Department of Brain Sciences, Imperial College London, London, UK.
  • Nabavi SM; Department of Brain and Cognitive Sciences, Cell Science Research Centre and Regenerative Medicine Department, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran.
  • Oliveri RS; Cell Therapy Unit, Department of Clinical Immunology, University of Copenhagen and Rigshospitalet, Copenhagen, Denmark.
  • Radue E; Medical Image Analysis Centre and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Ramo Tello C; Multiple Sclerosis Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Schiavetti I; Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Sellner J; Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University, Salzburg, Austria; Department of Neurology, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria.
  • Sorensen PS; Danish Multiple Sclerosis Centre, Department of Neurology, University of Copenhagen and Rigshospitalet, Copenhagen, Denmark.
  • Sormani MP; Department of Health Sciences, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Wuerfel JT; Medical Image Analysis Centre and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Freedman MS; Department of Medicine, University of Ottawa, Ottawa, ON, Canada; The Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: mfreedman@toh.ca.
Lancet Neurol ; 20(11): 917-929, 2021 11.
Article in En | MEDLINE | ID: mdl-34687636
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malformations of Cortical Development / Mesenchymal Stem Cells / Multiple Sclerosis Type of study: Clinical_trials Limits: Adolescent / Adult / Humans / Middle aged Language: En Journal: Lancet Neurol Journal subject: NEUROLOGIA Year: 2021 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malformations of Cortical Development / Mesenchymal Stem Cells / Multiple Sclerosis Type of study: Clinical_trials Limits: Adolescent / Adult / Humans / Middle aged Language: En Journal: Lancet Neurol Journal subject: NEUROLOGIA Year: 2021 Document type: Article Country of publication: Reino Unido