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Inferred inactivation of the Cftr gene in the duodena of mice exposed to hexavalent chromium (Cr(VI)) in drinking water supports its tumor-suppressor status and implies its potential role in Cr(VI)-induced carcinogenesis of the small intestines.
Mezencev, Roman; Auerbach, Scott S.
Affiliation
  • Mezencev R; Center for Public Health and Environmental Assessment, Office of Research and Development, US EPA, Washington, DC, United States. Electronic address: Mezencev.Roman@epa.gov.
  • Auerbach SS; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States.
Toxicol Appl Pharmacol ; 433: 115773, 2021 12 15.
Article in En | MEDLINE | ID: mdl-34688701
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Pollutants, Chemical / Cell Transformation, Neoplastic / Chromium / Cystic Fibrosis Transmembrane Conductance Regulator / Gene Silencing / Tumor Suppressor Proteins / Duodenal Neoplasms / Duodenum Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2021 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Pollutants, Chemical / Cell Transformation, Neoplastic / Chromium / Cystic Fibrosis Transmembrane Conductance Regulator / Gene Silencing / Tumor Suppressor Proteins / Duodenal Neoplasms / Duodenum Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2021 Document type: Article Country of publication: Estados Unidos