The formation and repair of DNA double-strand breaks in mammalian meiosis.
Asian J Androl
; 23(6): 572-579, 2021.
Article
in En
| MEDLINE
| ID: mdl-34708719
ABSTRACT
Programmed DNA double-strand breaks (DSBs) are necessary for meiosis in mammals. A sufficient number of DSBs ensure the normal pairing/synapsis of homologous chromosomes. Abnormal DSB repair undermines meiosis, leading to sterility in mammals. The DSBs that initiate recombination are repaired as crossovers and noncrossovers, and crossovers are required for correct chromosome separation. Thus, the placement, timing, and frequency of crossover formation must be tightly controlled. Importantly, mutations in many genes related to the formation and repair of DSB result in infertility in humans. These mutations cause nonobstructive azoospermia in men, premature ovarian insufficiency and ovarian dysgenesis in women. Here, we have illustrated the formation and repair of DSB in mammals, summarized major factors influencing the formation of DSB and the theories of crossover regulation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Repair
/
DNA Breaks, Double-Stranded
/
Mammals
Limits:
Animals
/
Humans
Language:
En
Journal:
Asian J Androl
Journal subject:
MEDICINA REPRODUTIVA
/
UROLOGIA
Year:
2021
Document type:
Article
Affiliation country:
China