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Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies.
Guercio, Marika; Manni, Simona; Boffa, Iolanda; Caruso, Simona; Di Cecca, Stefano; Sinibaldi, Matilde; Abbaszadeh, Zeinab; Camera, Antonio; Ciccone, Roselia; Polito, Vinicia Assunta; Ferrandino, Francesca; Reddel, Sofia; Catanoso, Maria Luigia; Bocceri, Emilia; Del Bufalo, Francesca; Algeri, Mattia; De Angelis, Biagio; Quintarelli, Concetta; Locatelli, Franco.
Affiliation
  • Guercio M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Manni S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Boffa I; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Caruso S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Di Cecca S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Sinibaldi M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Abbaszadeh Z; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Camera A; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Ciccone R; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Polito VA; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Ferrandino F; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Reddel S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Catanoso ML; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Bocceri E; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Del Bufalo F; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Algeri M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • De Angelis B; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Quintarelli C; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Locatelli F; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Front Immunol ; 12: 755639, 2021.
Article in En | MEDLINE | ID: mdl-34737753
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, B-Cell / Immunotherapy, Adoptive / Lymphoma, B-Cell / Genes, Transgenic, Suicide / Caspase 9 / Receptors, Chimeric Antigen Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2021 Document type: Article Affiliation country: Italia Country of publication: Suiza
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, B-Cell / Immunotherapy, Adoptive / Lymphoma, B-Cell / Genes, Transgenic, Suicide / Caspase 9 / Receptors, Chimeric Antigen Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2021 Document type: Article Affiliation country: Italia Country of publication: Suiza