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Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aß Pathology in Transgenic Mice.
Hoffmann, Torsten; Rahfeld, Jens-Ulrich; Schenk, Mathias; Ponath, Falk; Makioka, Koki; Hutter-Paier, Birgit; Lues, Inge; Lemere, Cynthia A; Schilling, Stephan.
Affiliation
  • Hoffmann T; Vivoryon Therapeutics N.V., Weinbergweg 22, 06120 Halle, Germany.
  • Rahfeld JU; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle, Germany.
  • Schenk M; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle, Germany.
  • Ponath F; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Rd., Boston, MA 02115, USA.
  • Makioka K; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Rd., Boston, MA 02115, USA.
  • Hutter-Paier B; QPS Austria GmbH, Department of Neuropharmacology, Parkring 12, A-8074 Grambach, Austria.
  • Lues I; Vivoryon Therapeutics N.V., Weinbergweg 22, 06120 Halle, Germany.
  • Lemere CA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Rd., Boston, MA 02115, USA.
  • Schilling S; Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle, Germany.
Int J Mol Sci ; 22(21)2021 Oct 30.
Article in En | MEDLINE | ID: mdl-34769222
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Benzimidazoles / Amyloid beta-Peptides / Aminoacyltransferases / Imidazolines / Antibodies, Monoclonal, Murine-Derived / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Alemania
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Benzimidazoles / Amyloid beta-Peptides / Aminoacyltransferases / Imidazolines / Antibodies, Monoclonal, Murine-Derived / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Alemania