The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.

Wu, Kelvin Ka Lok; Long, KeKao; Lin, Huige; Siu, Parco Ming Fai; Hoo, Ruby Lai Chong; Ye, Dewei; Xu, Aimin; Cheng, Kenneth King Yip

Wu, Kelvin Ka Lok; Long, KeKao; Lin, Huige; Siu, Parco Ming Fai; Hoo, Ruby Lai Chong; Ye, Dewei; Xu, Aimin; Cheng, Kenneth King Yip.

Affiliation

Wu KKL; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Long K; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Lin H; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Siu PMF; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
Hoo RLC; The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
Ye D; Department of Pharmacology & Pharmacy, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
Xu A; Guangdong Research Center of Metabolic Diseases of Integrated Western and Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Cheng KKY; The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.

Nat Commun ; 12(1): 6637, 2021 11 17.

Article in En | MEDLINE | ID: mdl-34789781

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Rab5 GTP-Binding Proteins / Adaptor Proteins, Signal Transducing / Inflammasomes / Mitophagy / NLR Family, Pyrin Domain-Containing 3 Protein / Macrophages Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: China

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