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Identification of raloxifene as a novel α-glucosidase inhibitor using a systematic drug repurposing approach in combination with cross molecular docking-based virtual screening and experimental verification.
Wu, Jiaofeng; Hu, Baichun; Lu, Shuaizhong; Duan, Rong; Deng, Haoran; Li, Lele; He, Lijuan; Zhao, Yunli; Wang, Jian; Yu, Zhiguo.
Affiliation
  • Wu J; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Hu B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Lu S; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Duan R; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Deng H; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Li L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • He L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Zhao Y; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Wang J; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Key Laboratory of Structure-Based Drug Design &Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: jianwang@syphu.edu.cn.
  • Yu Z; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: zhiguo-yu@163.com.
Carbohydr Res ; 511: 108478, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34801925

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Repositioning / Glycoside Hydrolase Inhibitors Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Carbohydr Res Year: 2022 Document type: Article Country of publication: Países Bajos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Repositioning / Glycoside Hydrolase Inhibitors Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Carbohydr Res Year: 2022 Document type: Article Country of publication: Países Bajos