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Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide.
Liew, Sook-Lei; Zavaliangos-Petropulu, Artemis; Schweighofer, Nicolas; Jahanshad, Neda; Lang, Catherine E; Lohse, Keith R; Banaj, Nerisa; Barisano, Giuseppe; Baugh, Lee A; Bhattacharya, Anup K; Bigjahan, Bavrina; Borich, Michael R; Boyd, Lara A; Brodtmann, Amy; Buetefisch, Cathrin M; Byblow, Winston D; Cassidy, Jessica M; Charalambous, Charalambos C; Ciullo, Valentina; Conforto, Adriana B; Craddock, Richard C; Dula, Adrienne N; Egorova, Natalia; Feng, Wuwei; Fercho, Kelene A; Gregory, Chris M; Hanlon, Colleen A; Hayward, Kathryn S; Holguin, Jess A; Hordacre, Brenton; Hwang, Darryl H; Kautz, Steven A; Khlif, Mohamed Salah; Kim, Bokkyu; Kim, Hosung; Kuceyeski, Amy; Lo, Bethany; Liu, Jingchun; Lin, David; Lotze, Martin; MacIntosh, Bradley J; Margetis, John L; Mohamed, Feroze B; Nordvik, Jan Egil; Petoe, Matthew A; Piras, Fabrizio; Raju, Sharmila; Ramos-Murguialday, Ander; Revill, Kate P; Roberts, Pamela.
Affiliation
  • Liew SL; Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.
  • Zavaliangos-Petropulu A; Keck School of Medicine, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
  • Schweighofer N; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
  • Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Lang CE; Biokinesiology and Physical Therapy, Ostrow School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Lohse KR; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Banaj N; Departments of Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
  • Barisano G; Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA.
  • Baugh LA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Bhattacharya AK; Department of Health and Kinesiology, University of Utah, Salt Lake City, UT, USA.
  • Bigjahan B; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Borich MR; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
  • Boyd LA; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Brodtmann A; Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
  • Buetefisch CM; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.
  • Byblow WD; Center for Brain and Behavior Research, Vermillion, SD, USA.
  • Cassidy JM; Sanford Research, Sioux Falls, SD, USA.
  • Charalambous CC; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Ciullo V; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Conforto AB; Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
  • Craddock RC; Department of Physical Therapy & the Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Dula AN; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.
  • Egorova N; Eastern Cognitive Disorders Clinic, Monash University, Melbourne, VIC, Australia.
  • Feng W; Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA.
  • Fercho KA; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA.
  • Gregory CM; Department of Radiology, Emory University, Atlanta, GA, USA.
  • Hanlon CA; Department of Exercise Sciences and Centre for Brain Research, University of Auckland, Auckland, New Zealand.
  • Hayward KS; Allied Health Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Holguin JA; Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus.
  • Hordacre B; Center for Neuroscience and Integrative Brain Research (CENIBRE), University of Nicosia Medical School, Nicosia, Cyprus.
  • Hwang DH; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Kautz SA; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
  • Khlif MS; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
  • Kim B; Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
  • Kim H; Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
  • Kuceyeski A; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.
  • Lo B; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia.
  • Liu J; Department of Health Sciences & Research, Medical University of South Carolina, Charleston, SC, USA.
  • Lin D; Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA.
  • Lotze M; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
  • MacIntosh BJ; Department of Health Sciences & Research, Medical University of South Carolina, Charleston, SC, USA.
  • Margetis JL; Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA.
  • Mohamed FB; College of Health Professions, Medical University of South Carolina, Charleston, SC, USA.
  • Nordvik JE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, VIC, Australia.
  • Petoe MA; Department of Physiotherapy, University of Melbourne, Heidelberg, VIC, Australia.
  • Piras F; NHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of Melbourne, Heidelberg, VIC, Australia.
  • Raju S; Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.
  • Ramos-Murguialday A; Innovation, IMPlementation and Clinical Translation (IIMPACT) in Health, Allied Health and Human Performance, University of South Australia, Adelaide, SA, Australia.
  • Revill KP; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Roberts P; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Brain Commun ; 3(4): fcab254, 2021.
Article in En | MEDLINE | ID: mdl-34805997
ABSTRACT
Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P < 0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. Worse sensorimotor behaviour was associated with a smaller ipsilesional thalamic volume in both early (n = 179; d = 0.68) and subacute (n = 274, d = 0.46) stroke. In chronic stroke (n = 404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d = 0.52) and nucleus accumbens (d = 0.39) volumes, and a larger ipsilesional lateral ventricle (d = -0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n = 256) was associated with smaller ipsilesional putamen (d = 0.72) and larger lateral ventricle (d = -0.41) volumes, while several measures of activity limitations (n = 116) showed no significant relationships. In the full cohort across all time (n = 828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d = 0.23), putamen (d = 0.33), thalamus (d = 0.33) and lateral ventricle (d = -0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Brain Commun Year: 2021 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Brain Commun Year: 2021 Document type: Article Affiliation country: Estados Unidos