Metabolism­related pharmacokinetic drug­drug interactions with poly (ADP­ribose) polymerase inhibitors (Review).

ABSTRACT

Poly (ADP­ribose) polymerase (PARP) inhibitors, including olaparib, niraparib, rucaparib, talazoparib and veliparib, have emerged as one of the most exciting new treatments for solid tumors, particularly in patients with breast­related cancer antigen 1/2 mutations. Oral administration is convenient and shows favorable compliance with the majority of patients, but it may be affected by numerous factors, including food, metabolic enzymes and transporters. These interactions may be associated with serious adverse drug reactions or may reduce the treatment efficacy of PARP inhibitors. In fact, numerous pharmacokinetic (PK)­based drug­drug interactions (DDIs) involve the metabolism of PARP inhibitors, particularly those metabolized via cytochrome P450 enzymes. The present review aims to characterize and summarize the metabolism­related PK­based DDIs of PARP inhibitors, and to provide specific recommendations for reducing the risk of clinically significant DDIs.