Oral coniferyl ferulate attenuated depression symptoms in mice via reshaping gut microbiota and microbial metabolism.
Food Funct
; 12(24): 12550-12564, 2021 Dec 13.
Article
in En
| MEDLINE
| ID: mdl-34812830
ABSTRACT
The gut microbiome is known to be involved in depression development. Thus, phytochemicals changing gut microbiota may alleviate depression-like behaviors. Coniferyl ferulate (CF) is a long studied natural product and known to alleviate psychiatric disorders. However, its mechanism of action remains unclear. In this experimental study, oral administration of 50 mg kg-1 CF once daily attenuated weight loss and depression-like and anxiety-like behaviors induced by chronic unpredicted mild stress (CUMS) in mice. Four weeks of CF administration significantly ameliorated colonic inflammation, lowered the levels of IL-6, IL-1ß, and TNF-α, and restructured the gut microbiome, and microbial metabolism. Intestinal microbiota can impact the development and function of the brain via the microbiota-gut-brain axis. Therefore, oral administration of CF is a promising nutritional strategy to treat CUMS-induced depression via the regulation of microbiota and microbial metabolism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Behavior, Animal
/
Coumaric Acids
/
Depression
/
Gastrointestinal Microbiome
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Food Funct
Year:
2021
Document type:
Article
Affiliation country:
China