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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Schmelz, Karin; Toedling, Joern; Huska, Matt; Cwikla, Maja C; Kruetzfeldt, Louisa-Marie; Proba, Jutta; Ambros, Peter F; Ambros, Inge M; Boral, Sengül; Lodrini, Marco; Chen, Celine Y; Burkert, Martin; Guergen, Dennis; Szymansky, Annabell; Astrahantseff, Kathy; Kuenkele, Annette; Haase, Kerstin; Fischer, Matthias; Deubzer, Hedwig E; Hertwig, Falk; Hundsdoerfer, Patrick; Henssen, Anton G; Schwarz, Roland F; Schulte, Johannes H; Eggert, Angelika.
Affiliation
  • Schmelz K; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Toedling J; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.
  • Huska M; The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Cwikla MC; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Kruetzfeldt LM; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.
  • Proba J; The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Ambros PF; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Ambros IM; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Boral S; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Lodrini M; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Chen CY; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Burkert M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090, Vienna, Austria.
  • Guergen D; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090, Vienna, Austria.
  • Szymansky A; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Astrahantseff K; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Kuenkele A; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.
  • Haase K; The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Fischer M; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Deubzer HE; Experimental and Clinical Research Center (ECRC) of the Charité and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Hertwig F; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Hundsdoerfer P; Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO), Berlin, Germany.
  • Henssen AG; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Schwarz RF; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Schulte JH; Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Eggert A; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.
Nat Commun ; 12(1): 6804, 2021 11 23.
Article in En | MEDLINE | ID: mdl-34815394
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Genetic Heterogeneity / Neoadjuvant Therapy / Clinical Decision-Making / Neuroblastoma Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Genetic Heterogeneity / Neoadjuvant Therapy / Clinical Decision-Making / Neuroblastoma Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Alemania