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Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice.
Xu, Xiaxia; Song, Lingzhen; Kringel, Rebecca; Hanganu-Opatz, Ileana L.
Affiliation
  • Xu X; Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany. xiaxia.xu@zmnh.uni-hamburg.de.
  • Song L; Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
  • Kringel R; Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
  • Hanganu-Opatz IL; Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany. hangop@zmnh.uni-hamburg.de.
Nat Commun ; 12(1): 6810, 2021 11 23.
Article in En | MEDLINE | ID: mdl-34815409
The prefrontal-hippocampal dysfunction that underlies cognitive deficits in mental disorders emerges during early development. The lateral entorhinal cortex (LEC) is tightly interconnected with both prefrontal cortex (PFC) and hippocampus (HP), yet its contribution to the early dysfunction is fully unknown. Here we show that mice that mimic the dual genetic (G) -environmental (E) etiology (GE mice) of psychiatric risk have poor LEC-dependent recognition memory at pre-juvenile age and abnormal communication within LEC-HP-PFC networks throughout development. These functional and behavioral deficits relate to sparser projections from LEC to CA1 and decreased efficiency of axonal terminals to activate the hippocampal circuits in neonatal GE mice. In contrast, the direct entorhinal drive to PFC is not affected, yet the PFC is indirectly compromised, as target of the under-activated HP. Thus, the entorhinal-hippocampal circuit is already impaired from neonatal age on in GE mice.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prefrontal Cortex / Entorhinal Cortex / CA1 Region, Hippocampal / Cognitive Dysfunction / Mental Disorders Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prefrontal Cortex / Entorhinal Cortex / CA1 Region, Hippocampal / Cognitive Dysfunction / Mental Disorders Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido